| 8/28 | H | Waterford (5-5) | [VII:27] | W | 22-6 | |
| 9/4 | A | Warren (7-2) | [IV:15] | W | 27-20 | |
| 9/11 | A | Caldwell (6-3) | [VII:27] | W | 26-0 | |
| 9/18 | H | Williamstown (WV) (5-2) | [IV] | W | 49-7 | |
| 9/25 | A | Wellston (5-3) | [V:19] | W | 28-6 | |
| 10/2 | A | Wheeling Central Catholic (WV) (6-3) | W | 33-0 | ||
| 10/17 | H | # Belpre (3-5) | [VI:23] | W | 54-0 | |
| 10/24 | H | # Africentric Early College (4-2) | [VI:23] | W | 51-12 | |
| 10/31 | H | # Barnesville (6-3) | [VI:23] | W | 34-0 | |
| 11/7 | H | # Fairland (8-2) | [VI:23] | W | 47-7 | |
| 11/14 | N | # Springfield (11-1) | [VI:21] | L | 13-16 | |
| # - Ohio playoff game | ||||||