| 8/25 | A | Sycamore (5-5) | [1:4] | W | 45-14 | |
| 9/1 | H | Glenville (9-2) | [1:1] | W | 26-6 | |
| 9/7 | H | Western Hills (4-5) | [1:4] | W | 48-6 | |
| 9/14 | H | Indianapolis Emmerich Manual (IN) (1-9) | [2:0] | W | 41-6 | |
| 9/22 | H | St Ignatius (11-4) | [1:1] | W | 23-7 | |
| 9/28 | A | La Salle (1-9) | [1:4] | W | 39-0 | |
| 10/5 | H | Archbishop Moeller (5-5) | [1:4] | W | 43-6 | |
| 10/12 | A | St Xavier (13-1) | [1:4] | L | 13-16 | |
| 10/20 | H | Warren G Harding (11-2) | [1:1] | W | 24-14 | |
| 10/26 | A | Oak Hills (4-6) | [1:4] | W | 39-22 | |
| 11/3 | H | # Lebanon (9-2) | [1:4] | W | 38-13 | |
| 11/10 | A | # Colerain (11-1) | [1:4] | W | 35-21 | |
| 11/17 | A | # St Xavier (13-1) | [1:4] | L | 21-24 | |
| # - Ohio playoff game | ||||||