| 8/29 | N | La Salle (14-1) | [2:6] | L | 21-40 | |
| 9/5 | A | St Xavier (10-3) | [1:2] | L | 12-31 | |
| 9/12 | H | Trinity (Louisville) (KY) (5-5) | [1:0] | L | 27-36 | |
| 9/19 | H | Fairfield (6-4) | [1:2] | W | 24-7 | |
| 9/26 | A | Lakota West (7-6) | [1:2] | W | 30-21 | |
| 10/3 | H | Lakota East (9-3) | [1:2] | W | 49-48 | 2 ot |
| 10/10 | A | Hamilton (0-10) | [1:2] | W | 42-14 | |
| 10/17 | H | Princeton (2-8) | [2:6] | W | 49-7 | |
| 10/24 | A | Sycamore (6-4) | [1:2] | W | 55-28 | |
| 10/31 | H | Oak Hills (2-8) | [1:2] | W | 22-0 | |
| 11/8 | A | # Hilliard Darby (9-2) | [1:2] | W | 28-7 | |
| 11/15 | N | # St Xavier (10-3) | [1:2] | L | 21-29 | |
| # - Ohio playoff game | ||||||