| 8/18 | A | Harvest Prep (12-2) | [V:19] | L | 16-38 | |
| 8/25 | H | Bishop Hartley (10-3) | [IV:15] | W | 28-17 | |
| 9/1 | A | Jonathan Alder (7-4) | [IV:15] | W | 42-0 | |
| 9/8 | A | Amanda-Clearcreek (3-7) | [V:19] | W | 41-7 | |
| 9/15 | H | Liberty Union (1-9) | [V:19] | W | 35-15 | |
| 9/22 | H | Fairfield Union (6-4) | [IV:15] | W | 45-3 | |
| 9/29 | A | Logan Elm (9-2) | [IV:15] | W | 35-6 | |
| 10/6 | H | Teays Valley (4-6) | [II:7] | W | 42-7 | |
| 10/13 | A | Hamilton Township (9-2) | [III:11] | L | 28-31 | |
| 10/20 | H | Circleville (1-9) | [III:11] | W | 40-0 | |
| 10/27 | H | # Athens (6-5) | [III:11] | W | 58-14 | |
| 11/3 | A | # Jackson (10-2) | [III:11] | W | 14-10 | |
| 11/10 | N | # Bishop Watterson (14-2) | [III:11] | L | 10-20 | |
| # - Ohio playoff game | ||||||