| 8/29 | A | Ridgewood (10-2) | [5:17] | L | 20-41 | |
| 9/5 | H | Wheeling Central Catholic (WV) (9-1) | [6:0] | L | 3-20 | |
| 9/11 | A | Harrison Central (8-3) | [5:17] | L | 3-21 | |
| 9/18 | A | John Marshall (WV) (5-5) | [2:0] | L | 10-27 | |
| 9/25 | A | Buckeye Local (0-10) | [4:13] | W | 56-7 | |
| 10/3 | H | Catholic Central (6-4) | [6:21] | L | 14-40 | |
| 10/10 | H | St Clairsville (9-2) | [4:13] | L | 21-36 | |
| 10/17 | H | Shadyside (4-7) | [7:25] | L | 0-14 | |
| 10/23 | A | Union Local (4-6) | [5:17] | W | 36-26 | |
| 10/31 | H | Martins Ferry (5-5) | [5:17] | L | 7-35 |