| 8/17 | H | Alexander (2-8) | [V:19] | W | 20-0 | |
| 8/25 | A | Caldwell (11-4) | [VII:27] | L | 14-41 | |
| 9/1 | H | Shenandoah (3-7) | [VI:23] | W | 24-22 | |
| 9/8 | A | Belpre (1-9) | [VI:23] | W | 47-6 | |
| 9/15 | A | Eastern (12-2) | [VII:27] | L | 20-21 | |
| 9/22 | A | Frontier (1-9) | [VII:27] | W | 31-0 | |
| 9/29 | A | Southern (3-7) | [VII:27] | W | 49-7 | |
| 10/6 | H | Harrison Central (9-3) | [V:17] | L | 14-28 | |
| 10/13 | H | Trimble (6-5) | [VI:23] | W | 14-8 | |
| 10/20 | H | Fort Frye (10-3) | [VI:23] | L | 0-16 | |
| 10/27 | H | # Miller (6-5) | [VII:27] | W | 35-12 | |
| 11/3 | A | # Eastern (11-1) | [VII:27] | W | 26-21 | |
| 11/10 | N | # Caldwell (11-4) | [VII:27] | L | 13-20 | |
| # - Ohio playoff game | ||||||