| 8/19 | A | Crooksville (0-10) | [VI:23] | W | 18-6 | |
| 8/26 | H | Williamstown (WV) (8-1) | [IV] | L | 22-46 | |
| 9/2 | A | Shenandoah (7-5) | [VI:23] | L | 13-18 | |
| 9/9 | A | Fort Frye (13-2) | [VI:23] | L | 19-49 | |
| 9/16 | H | Eastern (9-3) | [VII:27] | W | 29-13 | |
| 9/23 | H | Frontier (3-8) | [VII:27] | W | 41-0 | |
| 9/30 | A | South Gallia (4-7) | [VII:27] | W | 47-0 | |
| 10/7 | H | Southern (4-7) | [VII:27] | W | 44-6 | |
| 10/14 | A | Trimble (3-7) | [VI:23] | W | 30-6 | |
| 10/21 | H | Belpre (0-9) | [VI:23] | W | 47-0 | |
| 10/28 | H | # Southern (4-7) | [VII:27] | W | 49-6 | |
| 11/4 | A | # Eastern (9-3) | [VII:27] | W | 34-7 | |
| 11/12 | N | # Newark Catholic (11-2) | [VII:27] | L | 7-35 | |
| # - Ohio playoff game | ||||||