| 8/29 | A | Wellsville (7-4) | [7:23] | L | 7-24 | |
| 9/5 | A | Bridgeport (6-4) | [7:25] | W | 36-8 | |
| 9/12 | H | Fairport Harding (1-9) | [7:23] | W | 40-6 | |
| 9/19 | H | Catholic Central (6-4) | [7:23] | W | 34-7 | |
| 9/26 | H | Shadyside (11-1) | [7:25] | L | 6-33 | |
| 10/3 | A | St John (0-7) | [7:23] | W | 44-0 | |
| 10/10 | H | Beallsville (1-9) | [7:25] | W | 41-0 | |
| 10/17 | A | Conotton Valley (0-10) | [7:25] | W | 63-6 | |
| 10/24 | H | Paden City (WV) (4-6) | [7:0] | W | 48-18 | |
| 10/31 | A | Madonna (WV) (2-8) | [6:0] | W | 39-14 | |
| 11/8 | A | # Western Reserve (11-2) | [7:23] | L | 17-27 | |
| # - Ohio playoff game | ||||||