| 8/18 | H | Martins Ferry (5-6) | [VI:23] | L | 36-39 | |
| 8/25 | A | Shenandoah (3-7) | [VI:23] | L | 14-53 | |
| 9/1 | A | Buckeye Local (1-9) | [IV:15] | W | 26-0 | |
| 9/8 | H | Bellaire (5-6) | [VI:23] | L | 12-42 | |
| 9/15 | A | Brownsville (PA) (1-6) | [V] | W | 37-16 | |
| 9/22 | A | Barnesville (12-1) | [V:19] | L | 0-53 | |
| 9/29 | H | River (9-3) | [VII:27] | L | 20-53 | |
| 10/6 | A | Wheeling Central Catholic (WV) (5-5) | [VI] | L | 14-48 | |
| 10/13 | H | Bridgeport (3-8) | [VII:27] | W | 41-7 | |
| 10/20 | A | Monroe Central (7-5) | [VII:27] | L | 12-35 | |
| 10/27 | A | # Eastern (11-1) | [VII:27] | L | 27-41 | |
| # - Ohio playoff game | ||||||