| 8/18 | A | Canton South (14-1) | [IV:13] | L | 40-42 | |
| 8/25 | A | Martins Ferry (5-6) | [VI:23] | W | 54-0 | |
| 9/1 | H | Zanesville (1-9) | [III:11] | W | 48-7 | |
| 9/8 | A | Wheeling Central Catholic (WV) (5-5) | [VI] | W | 60-24 | |
| 9/15 | H | Indian Valley (9-4) | [IV:15] | W | 24-20 | |
| 9/22 | H | Harrison Central (9-3) | [V:17] | W | 49-8 | |
| 9/30 | A | Bellaire (5-6) | [VI:23] | W | 34-14 | |
| 10/6 | H | Union Local (6-5) | [V:19] | W | 39-6 | |
| 10/13 | H | Wheeling Park (WV) (7-2) | [II] | L | 14-21 | |
| 10/20 | H | Cambridge (0-10) | [IV:15] | W | 55-13 | |
| 10/27 | H | # Marion-Franklin (6-5) | [IV:15] | W | 44-12 | |
| 11/3 | A | # Bishop Hartley (10-3) | [IV:15] | L | 13-23 | |
| # - Ohio playoff game | ||||||