| 8/29 | A | Kettering Fairmont (6-4) | [1:2] | W | 42-12 | |
| 9/5 | A | Withrow (0-10) | [2:6] | W | 58-7 | |
| 9/12 | A | Thurgood Marshall (6-4) | [3:10] | W | 42-14 | |
| 9/19 | H | Bishop Fenwick (6-4) | [4:14] | W | 35-13 | |
| 9/26 | H | Roger Bacon (4-6) | [5:18] | W | 49-0 | |
| 10/3 | A | Purcell Marian (3-7) | [5:18] | W | 35-0 | |
| 10/10 | H | Badin (8-4) | [5:18] | W | 56-20 | |
| 10/18 | A | Archbishop McNicholas (10-2) | [4:14] | W | 49-0 | |
| 10/24 | A | Carroll (2-8) | [3:10] | W | 49-0 | |
| 10/31 | H | Chaminade-Julienne (5-5) | [5:18] | W | 42-21 | |
| 11/7 | H | # Miami Trace (7-4) | [4:14] | W | 49-7 | |
| 11/14 | N | # Wyoming (10-2) | [4:14] | W | 42-28 | |
| 11/21 | N | # Clinton-Massie (12-1) | [4:14] | W | 35-7 | |
| 11/28 | N | # Kenton (11-3) | [4:12] | W | 25-22 | |
| 12/5 | N | # Benedictine (14-1) | [4:11] | L | 14-21 | |
| # - Ohio playoff game | ||||||