| 8/30 | A | Kettering Fairmont (2-8) | [1:2] | W | 17-14 | |
| 9/7 | N | Guerin Catholic (IN) (3-7) | [3:0] | W | 34-3 | |
| 9/13 | H | Thurgood Marshall (7-4) | [3:10] | L | 14-34 | |
| 9/20 | A | Roger Bacon (4-6) | [5:18] | W | 9-0 | |
| 9/27 | H | Purcell Marian (3-7) | [5:18] | W | 24-7 | |
| 10/4 | A | Badin (10-3) | [5:18] | W | 49-3 | |
| 10/11 | H | Archbishop McNicholas (9-3) | [4:14] | W | 51-20 | |
| 10/18 | H | Carroll (2-8) | [3:10] | W | 49-0 | |
| 10/24 | A | Bishop Fenwick (6-4) | [4:14] | W | 21-0 | |
| 11/2 | A | Chaminade-Julienne (6-5) | [5:18] | W | 40-14 | |
| 11/8 | H | # Wyoming (8-3) | [4:14] | W | 35-21 | |
| 11/15 | N | # Valley View (10-2) | [4:14] | W | 28-0 | |
| 11/22 | N | # Clinton-Massie (14-1) | [4:14] | L | 14-21 | |
| # - Ohio playoff game | ||||||