| 8/21 | A | Trimble (8-3) | [VII:27] | L | 6-7 | |
| 8/27 | H | Newark Catholic (14-2) | [VII:27] | L | 14-38 | |
| 9/3 | A | Liberty Union (6-5) | [V:19] | L | 6-14 | |
| 9/10 | H | River Valley (2-6) | [V:19] | W | 48-13 | |
| 9/17 | H | Oak Hill (1-9) | [V:19] | W | 37-0 | |
| 9/24 | A | Meigs (3-6) | [V:19] | W | 13-6 | |
| 10/1 | H | Wellston (5-6) | [V:19] | W | 40-21 | |
| 10/8 | A | Alexander (3-7) | [V:19] | W | 35-0 | |
| 10/15 | H | Vinton County (6-4) | [IV:15] | W | 20-7 | |
| 10/22 | A | Athens (3-7) | [III:11] | W | 41-6 | |
| 10/30 | H | # Centerburg (6-4) | [VI:23] | W | 42-9 | |
| 11/6 | A | # Fort Frye (11-2) | [VI:23] | L | 6-36 | |
| # - Ohio playoff game | ||||||