| 8/23 | H | DeSales (Louisville) (0-1) | W | 38-7 | ||
| 8/30 | N | Henry Clay (0-3) | W | 48-7 | ||
| 9/6 | H | Male (Louisville) (2-0) | L | 14-51 | ||
| 9/13 | A | Central (Louisville) (0-1) | W | 23-0 | ||
| 9/20 | A | Bowling Green (0-2) | W | 28-14 | ||
| 9/27 | N | Trinity (Louisville) (8-2) | [1:0] | L | 3-35 | |
| 10/11 | A | DuPont Manual (1-0) | L | 19-20 | ||
| 10/18 | H | Butler (Louisville) (0-1) | W | 42-6 | ||
| 10/25 | A | Pleasure Ridge Park (0-1) | W | 36-13 | ||
| 11/1 | H | St Xavier (OH) (9-3) | [1:4] | L | 7-35 |