| 8/18 | H | Ben Davis (IN) (9-1) | [I] | L | 28-49 | |
| 8/25 | H | Fort Wayne Bishop Dwenger (IN) (5-5) | [III] | W | 57-0 | |
| 9/1 | A | East Central (IN) (10-0) | [II] | L | 28-38 | |
| 9/8 | A | Center Grove (IN) (9-1) | [I] | L | 34-35 | ot |
| 9/15 | H | St Xavier (7-5) | [I:4] | W | 20-10 | |
| 9/22 | H | La Salle (4-7) | [II:8] | W | 28-20 | |
| 9/29 | A | Elder (7-5) | [I:4] | W | 38-7 | |
| 10/7 | H | St Ignatius (3-9) | [I:1] | W | 47-7 | |
| 10/14 | A | St Edward (15-1) | [I:1] | L | 21-28 | |
| 10/20 | A | Detroit King (MI) (4-5) | [III] | W | 38-6 | |
| 10/27 | H | # West Clermont (4-7) | [I:4] | W | 49-13 | |
| 11/3 | A | # St Xavier (7-5) | [I:4] | W | 10-7 | |
| 11/10 | N | # Mason (7-6) | [I:4] | W | 38-3 | |
| 11/17 | N | # Lakota West (11-3) | [I:4] | W | 22-0 | |
| 11/24 | N | # Springfield (10-6) | [I:2] | L | 19-26 | ot |
| # - Ohio playoff game | ||||||