| 8/29 | N | Bishop Donahue (7-3) | [7:0] | L | 12-48 | |
| 9/6 | A | Valley (Wetzel) (3-7) | [7:0] | W | 26-9 | |
| 9/13 | H | Notre Dame (7-3) | [7:0] | L | 18-24 | |
| 9/20 | H | Beallsville (OH) (6-5) | [7:25] | L | 6-12 | |
| 9/27 | A | Madonna (10-0) | [6:0] | L | 6-48 | |
| 10/4 | H | Paden City (5-5) | [7:0] | W | 20-19 | |
| 10/11 | A | Hundred (0-9) | [7:0] | W | 57-16 | |
| 10/18 | H | Clay-Battelle (8-1) | [7:0] | L | 20-40 | |
| 10/25 | H | St John Central (OH) (0-10) | [7:25] | W | 51-15 | |
| 11/1 | A | Bridgeport (OH) (2-8) | [7:25] | W | 55-35 |